prep. 不管；尽管（自己）不愿意；不在乎；虽有
n. 侮辱；憎恨；怨恨；轻蔑的拒绝或不承认
despite作为介词具有不管；尽管（自己）不愿意；不在乎；虽有等意思，作为名词有侮辱；憎恨；怨恨；轻蔑的拒绝或不承认的意思，这里主要讲解despite作介词的用法
despite用作介词
despite用作介词时，与 in spite of同义，都表示“尽管”、“虽然”、“不顾”之意 放在句首时，要接成分，成分也就是句子的组成部分，由词或词组充当。
如：
Despite his advanced years，he is learning to drive． 虽然年事已高，他现在在学驾驶汽车。
Despite the drought，we expect a good crop． 尽管天旱，丰收依然在望。
1.表示尽管；虽然
Despite a thorough investigation, no trace of Dr Southwell has been found...
尽管进行了彻底的调查，还是没有发现索思韦尔博士的任何踪迹。
The National Health Service has visibly deteriorated, despite increased spending...
尽管支出在增加，但国民医疗保健服务的质量却明显下降了。
He was obviously distressed despite being unconscious...
虽然他自己未发觉，但他显然很忧心。
2.表示不由自主；情不自禁
If you do something despite yourself you do it although you did not really intend or expect to.
Despite myself, Harry's remarks had caused me to stop and reflect.
哈里的话让我不由自主地停下来细想。
despite of
不管， 尽管， 任凭;
Despite of their unproductive work, they mostly make good money.
尽管他们的非生产性工作，他们大多是好钱。
despite that+句子，其中that是作为宾语从句的先行词来用的,后面的句子就是个宾语从句
despite the fact that+句子
表示的意思是：尽管
in spite of
in spite of +宾语 作让步状语，表示“不顾”，“尽管”，“虽然”之意
in spite of the fact that xxx (从句)做”不顾XXX事实”讲
1. She persevered in her idea despite obvious objections raised by friends.
虽然朋友们明确反对，她还是坚持己见。
2. Despite his lack of experience, he got the job.
他虽然经验不足，但还是获得了这份工作。
3. Despite his bulk he moved lightly on his feet.
尽管他身形庞大，移动起来还是很灵巧。
4. Despite her status, the Duchess will not be given preferential treatment.
虽然地位显赫，但是公爵夫人并不会得到优待。
5. Despite his unconventional methods, he has inspired pupils more than anyone else.
尽管他的方法不同寻常，但他给予学生的激励比其他人都要多。
6. They were all in top hats and cutaways despite the growing heat.
虽然天气越来越热，他们仍全部戴着高顶礼帽，穿着燕尾服。